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Convalescent plasma, a COVID-19 immunotherapy, was granted emergency use authorization by the FDA in August 2020 for treatment of hospitalized patients early in the course of COVID-19 infection. According to a new study, the optimal time for donating convalescent plasma appears to be within 60 days of the onset of COVID-19 symptoms.

Researchers looked at levels of IgM, IgG, and virus neutralizing (VN) antibodies in 175 convalescent plasma donors over 142 days after their COVID- 19 symptoms began. IgMs are the first group of antibodies made after infection. After about 2 weeks, IgG antibodies are made; these are more durable and longer lasting. VN antibodies are IgM and IgG antibodies that bind directly to viruses and prevent them from entering cells. In the analysis, VN antibodies persisted for 100 days following the onset of COVID-19 symptoms; however, there was a significant decline in antibody titers by day 60. Donors between 20 and 30 years old had a faster decline in antibodies than those over the age of 30 years. Ideal donors had more severe disease and were over 60 years old.

Interested individuals should consider donating plasma soon after recovering from COVID-19 infection. For more information visit: Donate COVID-19 Plasma

• Gontu A. Commun Biol 2021; doi: 10.1038/ s42003-021-01813-y.


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